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The vaccine wars shouldn’t surprise us given how COVID has blighted life around the world – politica

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  • How does he tell the time.....?
    Probably looks at his phone.
  • I really hope the British media can resist the temptation to go full Sunday People and start printing loads of anacedotal stories of oldies who had had AZN vaccine having died, as a way of saying see should be following German approach.
  • EndillionEndillion Posts: 4,976

    Apols if already published, but this report on real-world Israeli experience with the Pfizer vaccine (ex-Guardian blog) is heartening: Seems thoroughly persuasive.

    -------
    One domestic healthcare provider, Maccabi, said today that out of 163,000 Israeli given both shots of the Pfizer-BioNtech vaccine, only 31 were infected with the coronavirus. That was compared with nearly 6,450 infections among a control group of unvaccinated people.

    Of the vaccinated people who were infected, none were hospitalised and only suffered mild effects, such as headaches. Maccabi said the data suggested the vaccine was 92% effective, close to the 95% that Pfizer claims.

    -------
    On the EU controversy, people are obviously not going to accept diverting vaccinations from high-risk recipients to go to the EU, but I wonder if an offer to share the Pfizer one once we've completed the over-60 range might be more acceptable. Are we really going to insist on vaccinating 30-year-olds as priority over a frail 80-year-old, just because the 30-year-old is British and the 80-year-old is Dutch?

    Yes. Vaccinations benefit wider society more than the individual being vaccinated. The more people have the vaccine, the safer everyone is, regardless of how old they are. The vaccine isn't 100% effective, so lockdown only ends once we reach some form of herd immunity.
  • Sky reporting AZ factory in Belgium was raided by Belgium authorities

    Full Cartman......
  • NigelbNigelb Posts: 76,495

    India, Pakistan, South Africa, Argentina and Mexico.

    About a third of the world's population already in countries using it.
    And South Africa, at least, are paying a lot more per dose than the EU (I'm not sure about the others).
  • turbotubbsturbotubbs Posts: 18,589
    Scott_xP said:
    Hopefully not because they've all died...
  • Cyclefree said:

    On topic, The Third Man is an outstanding film.

    An absolute must see.

    I think this is a topic on which all can agree.
  • TOPPINGTOPPING Posts: 43,668


    Tutima wrist watch, may not be now though :(
    Very nice. I am always amazed when magazines (and not just How to Spend It or Tatler) have articles about watches that routinely cost thousands upon thousands of pounds.

    Those look good.
  • LeonLeon Posts: 59,629

    Full Cartman......
    I believe (I might be wrong) this is the same inspection reported yesterday: the Belgians authorities went in to check what was being exported where. That's a long way from a "raid", so this might just be hyperbolic reportage. Which is not unknown
  • Leon said:

    I believe (I might be wrong) this is the same inspection reported yesterday: the Belgians authorities went in to check what was being exported where. That's a long way from a "raid", so this might just be hyperbolic reportage. Which is not unknown
    I know the EU have been happy to cosy up to the Chinese....but I didn't know they were going to be copying their approach to managing businesses.
  • I hate to be a pedant (that’s a lie) but starting with an all time peak of admissions, once you start to see a drop in cases the very nature of these being net numbers means you are almost guaranteed to see a record fall in hospitalised numbers.
  • IanB2 said:

    “everything?”
    Literally!
  • TOPPINGTOPPING Posts: 43,668
    Leon said:

    Well that was the express intent of the EU during the entire Brexit negotiations.

    They didn't just want us to fail, they DID THEIR BEST to make us fail.



    !I’ll have done my job if, in the end, the deal is so tough on the British that they’d prefer to stay in the EU”. Michel Barnier

    https://www.lepoint.fr/monde/brexit-les-secrets-d-un-bras-de-fer-historique-episode-1--28-11-2018-2275148_24.php
    Chalk and apples sunshine. One is a negotiation. The vaccine rollout is not us vs them.

    Although of course it is to many, esp. on here.
  • LeonLeon Posts: 59,629
    lol.

    Given the huge drop in cases, I think we can, however, be reassured that this is a genuine easing of pressure on the NHS. Indeed given the massive fall in cases, it would be very weird - and disturbing - if in-patient pressure HADN'T eased up
  • kle4kle4 Posts: 98,426
    Leon said:

    I believe (I might be wrong) this is the same inspection reported yesterday: the Belgians authorities went in to check what was being exported where. That's a long way from a "raid", so this might just be hyperbolic reportage. Which is not unknown
    Poor show by Sky if so. You cant just jazz up your descriptions for excitement value.

    Inspection and raid are not synonyms!
  • TOPPINGTOPPING Posts: 43,668
    Dura_Ace said:

    Don't bother. It's more hassle than it's worth now. The courier companies just make up charges at random. I bought about 100 quid worth of 2CV parts from the Netherlands and paid nearly 250 quid in various imposts on top.

    I buy and sell a lot of Porsche parts on eBay and the game is now fraudlent values with the balance made up en noir. Recently bought a 991.2 GT3RS ECU and key set for "80 euros". Lol.
    2CV? Does that mean you'll be heading to the country, with a dozen eggs and, erm, a top hat any time soon?
  • NickPalmerNickPalmer Posts: 21,673
    edited January 2021
    Endillion said:

    I'm confused. Why does Germany have a vaccine committee? Is this shorthand for the EMA, or does each EU country have to sign off separately?
    This is a draft recommendation from the Standing Vaccine Commission at the Robert Koch Institut, the leading German research body. It doesn't force the EMA to follow suit, but it's already been hinted that they are inclined to do so.

    We need to be clear that nobody is saying that they have evidence that the AZ vaccine is ineffective for elderly people, merely that the sample size for this age group is so small that it doesn't prove that it is effective. Since the effectiveness of the AZ vaccine is in any case thought from the clinical trial to be lower than the Pfizer vaccine, it does make sense to try to prioritise Pfizer for the most vulnerable groups. Other considerations (freezer storage, organisation) make this complicated, but it's sensible if it can be done.

    My impression is that in the UK we're just vaccinating as many as possible with whichever vaccine is to hand? That's understandable, but if we can tweak it to a "Pfizer if possible for the over-60s" policy that would make sense, and nothing to do with vaccine nationalism.
  • kinabalukinabalu Posts: 44,716
    Leon said:

    The EU is not Man United, the UK is not Stockport County. The EU isn't even United. As we see
    I didn't mean it literally. Global Britain is no Stockport County. C'mon. It's a Blackburn Rovers at the very least. And it is a mess on the EU side. But you will admit that the europhobe glee - which word I choose carefully - over this does have some of what I'm trying to get over. Pleasure in the misfortune of something to which one has both a superiority and inferiority complex. These 2 things do go together after all.
  • felixfelix Posts: 15,180

    Apols if already published, but this report on real-world Israeli experience with the Pfizer vaccine (ex-Guardian blog) is heartening: Seems thoroughly persuasive.

    -------
    One domestic healthcare provider, Maccabi, said today that out of 163,000 Israeli given both shots of the Pfizer-BioNtech vaccine, only 31 were infected with the coronavirus. That was compared with nearly 6,450 infections among a control group of unvaccinated people.

    Of the vaccinated people who were infected, none were hospitalised and only suffered mild effects, such as headaches. Maccabi said the data suggested the vaccine was 92% effective, close to the 95% that Pfizer claims.

    -------
    On the EU controversy, people are obviously not going to accept diverting vaccinations from high-risk recipients to go to the EU, but I wonder if an offer to share the Pfizer one once we've completed the over-60 range might be more acceptable. Are we really going to insist on vaccinating 30-year-olds as priority over a frail 80-year-old, just because the 30-year-old is British and the 80-year-old is Dutch?

    The EU have TODAY rejected asking the UK to help in mediation of the issue saying it's between them and AZN. I'm afraid the toys are still outside the pram.
  • LeonLeon Posts: 59,629
    TOPPING said:

    Chalk and apples sunshine. One is a negotiation. The vaccine rollout is not us vs them.

    Although of course it is to many, esp. on here.
    WTF are you on? Ketamine?

    The EU has just made vaccines all about us V them.

    Give us YOUR jabs or else. That is exactly what they have said

    https://twitter.com/DarrenEuronews/status/1354483646602817540?s=20
  • FF43FF43 Posts: 17,858
    edited January 2021
    This is interesting. The decision to authorise or not authorise the Astrazeneca vaccine for over 65s depends on precisely two datapoints. One in the vaccination group and one in the control group.

    As calculated, an efficacy rate of 6.3%, although this is clearly nonsense

    https://twitter.com/olivernmoody/status/1354781400071860230
  • CarnyxCarnyx Posts: 44,617

    Thanks, they don't have quite the model I was looking for, plus more expensive (even taking vat etc into account)!
    Just what you need on Sauciehall Street to keep up the gallus style.
  • TOPPINGTOPPING Posts: 43,668
    Leon said:

    WTF are you on? Ketamine?

    The EU has just made vaccines all about us V them.

    Give us YOUR jabs or else. That is exactly what they have said

    https://twitter.com/DarrenEuronews/status/1354483646602817540?s=20
    "They" haven't said anything of the sort. Peter Liese said it. Do you take everything Dennis Skinner or Bill Cash says in the HoC as "the UK says"?
  • contrariancontrarian Posts: 5,818

    I don't see a single person here "gleeful" that the EU is troubled.

    I see a lot of people acknowledging the EU is troubled, right down to williamglenn calling for UVDL's resignation on the subject. I see other people trying to whatabout or downplay just how serious this is.

    The EU aren't just failing to protect their own citizens, they're jeopardising us. The science and technology exists to eradicate this damned nasty bug but because they've chosen to cheap out on it instead its going to remain on our continent and risks mutation and reintroduction into this country.

    I don't see a single person happy about that.
    You clearly aren't following Nigel Farage's broadcasts....!
  • LeonLeon Posts: 59,629
    edited January 2021
    kinabalu said:

    I didn't mean it literally. Global Britain is no Stockport County. C'mon. It's a Blackburn Rovers at the very least. And it is a mess on the EU side. But you will admit that the europhobe glee - which word I choose carefully - over this does have some of what I'm trying to get over. Pleasure in the misfortune of something to which one has both a superiority and inferiority complex. These 2 things do go together after all.
    Go on Twitter and you'll find plenty of EU schadenfreude (see what I did there) over Britain's struggles with the virus. Just as they exulted in the problems of Brexit. This stuff goes both ways.

    There is no inferiority complex on either side on this vaccine issue. There is rivalry, panic, and some lingering bitterness over Brexit

    I will admit some Leavers have a mental problem, but it is, actually, more of a superiority complex. British exceptionalism. That really is a thing.
  • Andy_JSAndy_JS Posts: 34,288
    edited January 2021
    It'll be interesting to hear what the UK's vaccine experts have to say about whether or not the AZ jab should be used on the over 65s in response to the German decision.
  • MarqueeMarkMarqueeMark Posts: 54,461
    eek said:

    I have various options from an Ebel el primero to various Omegas but if I wear a watch nowadays its from Apple.
    The Omega Seamasters are nice, for sure.
  • TheuniondivvieTheuniondivvie Posts: 43,242
    edited January 2021
    kinabalu said:

    I didn't mean it literally. Global Britain is no Stockport County. C'mon. It's a Blackburn Rovers at the very least. And it is a mess on the EU side. But you will admit that the europhobe glee - which word I choose carefully - over this does have some of what I'm trying to get over. Pleasure in the misfortune of something to which one has both a superiority and inferiority complex. These 2 things do go together after all.
    I am reminded of Churchill's quote, "The Hun is always either at your throat or your feet….”.
    Perhaps the British stroke of genius is to adapt its German heritage to allow it to do both simultaneously.
  • BromBrom Posts: 3,760
    edited January 2021
    Hard to work out who's had a worse week - German politicians or EU ones. If they decide they're unwilling to use AZ for over 65s then it'll set them back months. If they're seriously going to slow the vaccine rollout to a snails pace and offer pensioners no vaccine rather than give them the AZ then they're crazy. They won't be able to get Pfizer all across the continent with ease and have nowhere near enough of Moderna.
  • williamglennwilliamglenn Posts: 54,747
    TOPPING said:

    "They" haven't said anything of the sort. Peter Liese said it. Do you take everything Dennis Skinner or Bill Cash says in the HoC as "the UK says"?
    The German Health Minister repeated today that any production constraints should hit everyone equally, i.e. supplies should be diverted from the UK. They are refusing to take responsibility for the consequences of their delay in signing the contract.
    https://twitter.com/BMG_Bund/status/1354717241061871617
  • FF43 said:

    This is interesting. The decision to authorise or not authorise the Astrazeneca vaccine for over 65s depends on precisely two datapoints. One in the vaccination group and one in the control group.

    As calculated, an efficacy rate of 6.3%, although this is clearly nonsense

    https://twitter.com/olivernmoody/status/1354781400071860230

    Pretty certain there were more cases in the data the UK regulatory looked at. But only, like, 12.
  • I don't think it is in doubt that in an ideal world the AZN would now be back doing new trials before any country approved it.

    And even Pfizer might have been asked to do some more safety studies, given how new the technology is.

    But we aren't in an ideal world.

    I actually think that by the time we have got through the UK population, we will probably be going back round again with a new vaccine to fight off all the mutant variants.

    Thus the arguments of individual efficacy I think a bit of a red herring. At the moment, it is about driving covid rates right down and especially serious cases, rather than total elimination.
  • kle4kle4 Posts: 98,426
    TOPPING said:

    "They" haven't said anything of the sort. Peter Liese said it. Do you take everything Dennis Skinner or Bill Cash says in the HoC as "the UK says"?
    It's certainly a fair point, though let us hope people do indeed not pretend things Cash or Swayne say as being 'the UK'.

    Though the BBC did report 'the EU' demand UK bound doses.
  • anothernickanothernick Posts: 3,591
    Nigelb said:

    .

    I believe that's what's called seeing conditions on the ground for himself...
    Well that is one way of describing it but it's yet another gift from the Tories to the SNP, free gratis and for nothing.

    The Scots have made up their minds about Boris and there's nothing he can do to change that.
  • How does he tell the time.....?
    He uses his phone for that.
  • LostPasswordLostPassword Posts: 19,155
    edited January 2021

    Isn't sucking up to China the exact opposite of Trumpism?
    No Trump was big on sucking up to Xi. He only soured on China later.
  • bigjohnowlsbigjohnowls Posts: 22,924
    Andy_JS said:

    It'll be interesting to hear what the UK's vaccine experts have to say about whether or not the AZ jab should be used on the over 65s in response to the German decision.

    It will.
  • TOPPINGTOPPING Posts: 43,668
    .

    I don't think it is in doubt that in an ideal world the AZN would now be back doing new trials before any country approved it.

    And even Pfizer might have been asked to do some more safety studies, given how new the technology is.

    But we aren't in an ideal world.

    I actually think that by the time we have got through the UK population, we will probably be going back round again with a new vaccine to fight off all the mutant variants.

    Thus the arguments of individual efficacy I think a bit of a red herring. At the moment, it is about driving covid rates right down and especially serious cases, rather than total elimination.

    All will tell in the hospitalisation rates.
  • TOPPINGTOPPING Posts: 43,668

    The German Health Minister repeated today that any production constraints should hit everyone equally, i.e. supplies should be diverted from the UK. They are refusing to take responsibility for the consequences of their delay in signing the contract.
    https://twitter.com/BMG_Bund/status/1354717241061871617
    Fuckers. Let's leave the EU and take charge of our own affairs.
  • eekeek Posts: 29,696

    Pretty certain there were more cases in the data the UK regulatory looked at. But only, like, 12.
    One thing that I can safely say about that figure is that 6.3% isn't the 8% that Germany paper was talking about.
  • MaxPBMaxPB Posts: 39,809
    eek said:

    One thing that I can safely say about that figure is that 6.3% isn't the 8% that Germany paper was talking about.
    Yes, that 8% gets more and more curious.
  • LeonLeon Posts: 59,629

    This is a draft recommendation from the Standing Vaccine Commission at the Robert Koch Institut, the leading German research body. It doesn't force the EMA to follow suit, but it's already been hinted that they are inclined to do so.

    We need to be clear that nobody is saying that they have evidence that the AZ vaccine is ineffective for elderly people, merely that the sample size for this age group is so small that it doesn't prove that it is effective. Since the effectiveness of the AZ vaccine is in any case thought from the clinical trial to be lower than the Pfizer vaccine, it does make sense to try to prioritise Pfizer for the most vulnerable groups. Other considerations (freezer storage, organisation) make this complicated, but it's sensible if it can be done.

    My impression is that in the UK we're just vaccinating as many as possible with whichever vaccine is to hand? That's understandable, but if we can tweak it to a "Pfizer if possible for the over-60s" policy that would make sense, and nothing to do with vaccine nationalism.
    Given the state Britain was in six weeks ago, it was the right choice to jab everyone with anything we had. Even if AZ is marginally less effective, especially in oldsters (tho we don't know that yet, and there is mounting evidence that it is good for all ages, from the Lancet report on) it was correct to use it. Also it is cheaper, sold not for profit, and it is much easier to disperse to fridges in GPs, pharmacies, and so on, meaning you can inject a lot more people than if you only use Pfizer, with its storage problems.

    And, as Max pointed out yesterday, giving everyone possible a much improved chance of not catching this - with any jab we have - is absolutely correct, as the fewer people infected means less chance of mutation.

    And that is now the real enemy of humanity: mutation

    We can defintely beat this bastard bug - as long as it does not mutate, yet again, into something even nastier

  • glwglw Posts: 10,349
    Brom said:

    Hard to work out who's had a worse week - German politicians or EU ones. If they decide they're unwilling to use AZ for over 65s then it'll set them back months. If they're seriously going to slow the vaccine rollout to a snails pace and offer pensioners no vaccine rather than give them the AZ then they're crazy. They won't be able to get Pfizer all across the continent with ease and have nowhere near enough of Moderna.

    They are taking a pessimistic interpretation of the admittedly limited data and not approving the use of the vaccine for the very group that could benefit the most. That might be fine if this was any other disease, but right now that will almost certainly result in thousands of avoidable deaths.
  • The German Health Minister repeated today that any production constraints should hit everyone equally, i.e. supplies should be diverted from the UK. They are refusing to take responsibility for the consequences of their delay in signing the contract.
    https://twitter.com/BMG_Bund/status/1354717241061871617
    If, as seems likely, we do not yield on this point then it’s an interesting and unpredictable first case study for our post Brexit relationship. Not a happy case study, or the one any of us would have hoped for to shape our relationship, but an interesting one.
  • Carnyx said:

    Just what you need on Sauciehall Street to keep up the gallus style.
    I fear Sauchiehall Street may err more on the Connor McGregor side of things (though sadly the only style being put on at the moment is post apocalyptic shuffling in the style of the The Road).
  • kinabalukinabalu Posts: 44,716

    I don't see a single person here "gleeful" that the EU is troubled.

    I see a lot of people acknowledging the EU is troubled, right down to williamglenn calling for UVDL's resignation on the subject. I see other people trying to whatabout or downplay just how serious this is.

    The EU aren't just failing to protect their own citizens, they're jeopardising us. The science and technology exists to eradicate this damned nasty bug but because they've chosen to cheap out on it instead its going to remain on our continent and risks mutation and reintroduction into this country.

    I don't see a single person happy about that.
    There is some glee. You can only see it if you're not feeling it.
  • Quite surprised to find out today several members of my extended family who are in the lower categories of the 1-4 groups have their vaccine appointments for next week.
  • contrariancontrarian Posts: 5,818
    If Vaccine-gate has exposed the EU's systemic weaknesses to a much wider audience, then that has implications.

    Why? well because the people who told us the EU was wonderful and we would shrivel and die without it are pretty much the same people who tell us

    Lockdowns are inevitable and necessary
    America has a liberal majority that was cheated in 2016 and triumphed in 2020
    and
    There's a climate emergency.

    And given these folk have been so spectacularly wrong about the EU, maybe some of their other beliefs are worth examining in more detail going forward
  • If someone would take out all the 700s on Luisa Porritt being next London Mayor it would be appreciated.

    n.b. i do not suggest this would be a good bet. Just that it would be appreciated.
  • kinabalukinabalu Posts: 44,716

    I understand the core point, and that’s their choice. It’s the broader comms and the leaking of the suggestion that it’s unsafe which I don’t understand. It benefits nobody.
    I haven't seen any leaking that it is unsafe. Only that its efficacy could be as low as 8%.
  • MaxPBMaxPB Posts: 39,809
    glw said:

    They are taking a pessimistic interpretation of the admittedly limited data and not approving the use of the vaccine for the very group that could benefit the most. That might be fine if this was any other disease, but right now that will almost certainly result in thousands of avoidable deaths.
    Especially when you consider that vaccination programmes haven't started for under 65s in any meaningful sense so it's not as if there is spare capacity created by switching it around. There is still going to be the same supply pressure on the Pfizer vaccine for another 2 or 3 months meaning those people who need to be immunised the most are going to be waiting while under 65s who need it a lot less will start getting their vaccines in a few weeks.

    It seems like a huge public health risk and if in two or three weeks the single jab shows the expected 70% immunity from symptoms in the UK I really hope they reverse this decision.
  • BromBrom Posts: 3,760
    glw said:

    They are taking a pessimistic interpretation of the admittedly limited data and not approving the use of the vaccine for the very group that could benefit the most. That might be fine if this was any other disease, but right now that will almost certainly result in thousands of avoidable deaths.
    Totally agree, this is a sprint not a marathon. This decision would render AZ pretty much useless to the EU until late Spring unless they're going to use their resources to simultaneously vaccinate the over and under 65s.

    It just makes the EU's aggression towards AZ's supply lines baffling if the EMA back the decision of the German regulator.
  • Casino_RoyaleCasino_Royale Posts: 62,176
    Surely the best way to troll the EU is to offer all of the European Commissioners priority AZ vaccines administered here in the UK as part of our effort to recognise their importance in strong bilateral relations?
  • RobDRobD Posts: 60,336
    IanB2 said:

    “everything?”
    That may have been deliberate. ;)
  • kle4kle4 Posts: 98,426
    kinabalu said:

    I haven't seen any leaking that it is unsafe. Only that its efficacy could be as low as 8%.
    Most people will probably hear something like that as meaning unsafe, even when under that worst case it's still technically better than nothing. But if its insufficient data behind decision leaking that it is proven low efficacy is reckless.
  • EndillionEndillion Posts: 4,976

    This is a draft recommendation from the Standing Vaccine Commission at the Robert Koch Institut, the leading German research body. It doesn't force the EMA to follow suit, but it's already been hinted that they are inclined to do so.

    We need to be clear that nobody is saying that they have evidence that the AZ vaccine is ineffective for elderly people, merely that the sample size for this age group is so small that it doesn't prove that it is effective. Since the effectiveness of the AZ vaccine is in any case thought from the clinical trial to be lower than the Pfizer vaccine, it does make sense to try to prioritise Pfizer for the most vulnerable groups. Other considerations (freezer storage, organisation) make this complicated, but it's sensible if it can be done.

    My impression is that in the UK we're just vaccinating as many as possible with whichever vaccine is to hand? That's understandable, but if we can tweak it to a "Pfizer if possible for the over-60s" policy that would make sense, and nothing to do with vaccine nationalism.
    Thank you. I thought the over 65s cohort was large enough (albeit still smaller than ideal) and the issue was with the 75+ group, but I may have that wrong.

    The UK is still vaccinating in descending age order (other than healthcare professionals), so most of the older groups will have had the Pfizer vaccine just because it arrived first and in greater quantities.
  • kinabalu said:

    There is some glee. You can only see it if you're not feeling it.
    Or if you're a paranoid fool who projects emotions onto others.

    I see more anger than glee. With an element of "I told you so" at the worst.

    Next time you criticise anyone should I use the word "glee" about your emotions at the time?
  • RobDRobD Posts: 60,336

    Pretty certain there were more cases in the data the UK regulatory looked at. But only, like, 12.
    So much for having newer data not considered by the MHRA.
  • MalmesburyMalmesbury Posts: 54,114
    England only data out

    1st dose 2nd dose Cumulative Total Doses to Date
    Total 251,902 1,090 252,992
    East Of England 24,773 51 24,824
    London 41,254 298 41,552
    Midlands 41,416 75 41,491
    North East And Yorkshire 38,606 76 38,682
    North West 38,266 408 38,674
    South East 37,176 125 37,301
    South West 28,317 53 28,370

    What kind of panic do you think we should go for? Running round with hair on fire? War with Erewhon?
  • kinabalukinabalu Posts: 44,716

    You clearly aren't following Nigel Farage's broadcasts....!
    :smile: - luvin it.
  • turbotubbsturbotubbs Posts: 18,589
    RobD said:

    So much for having newer data not considered by the MHRA.
    Is this possibly about age range? Where the boundaries looked at for over 55 by the MHRA, thus more cases (i.e. between 55 and 64?)
  • FF43FF43 Posts: 17,858

    I don't think it is in doubt that in an ideal world the AZN would now be back doing new trials before any country approved it.

    And even Pfizer might have been asked to do some more safety studies, given how new the technology is.

    But we aren't in an ideal world.

    I actually think that by the time we have got through the UK population, we will probably be going back round again with a new vaccine to fight off all the mutant variants.

    Thus the arguments of individual efficacy I think a bit of a red herring. At the moment, it is about driving covid rates right down and especially serious cases, rather than total elimination.

    I agree and am perfectly happy for my ninety year old mum, for example, to have the AZ vaccine. As long as we can be sure it's safe, whether it works is almost a bonus.

    But it does put regulators in a bind. They are supposed to be evidence led, but there doesn't seem to be the evidence right now to support an authorisation for this age group. At best there's a double negative: no evidence to suggest you shouldn't do it. No doubt, more data will come to light with new trials and deployment in the field. In the meantime we are not so much taking shortcuts with the regulatory process, as bypassing it and asking regulators to sign off on it.
  • SelebianSelebian Posts: 9,243
    edited January 2021
    FF43 said:

    This is interesting. The decision to authorise or not authorise the Astrazeneca vaccine for over 65s depends on precisely two datapoints. One in the vaccination group and one in the control group.

    As calculated, an efficacy rate of 6.3%, although this is clearly nonsense

    https://twitter.com/olivernmoody/status/1354781400071860230

    Well, you can look at that two ways:
    - No evidence AZN is effective in over 65s -> don't give the vaccine
    - No evidence AZN effectiveness in over 65s is different to effectiveness in under 65s, for whom it is effective -> give the vaccine
    Both technically true. Take your pick.

    I don't know whether this is done in the assessments/trials, but I'd be inclined (I'm no virologist, just an epidemiologist without expertise in this area; I've not even done much trial work) to try and model the response with age, e.g. interaction of age and vaccination status against infection risk, so that you can pick up whether there's evidence for a decrease in efficacy with age and the extent of that.

    Similar logic in whether you give two doses three weeks apart or delay the second dose. You don't have hard evidence that two doses further apart will be better overall as more get first dose, but you suspect it to be the case. Countries will make different decisions there too, of course.
  • England only data out

    1st dose 2nd dose Cumulative Total Doses to Date
    Total 251,902 1,090 252,992
    East Of England 24,773 51 24,824
    London 41,254 298 41,552
    Midlands 41,416 75 41,491
    North East And Yorkshire 38,606 76 38,682
    North West 38,266 408 38,674
    South East 37,176 125 37,301
    South West 28,317 53 28,370

    What kind of panic do you think we should go for? Running round with hair on fire? War with Erewhon?

    Now I think it is undisputable there are supply issues here in the UK....but our government aren't going full metal Cartman.
  • EndillionEndillion Posts: 4,976

    If someone would take out all the 700s on Luisa Porritt being next London Mayor it would be appreciated.

    n.b. i do not suggest this would be a good bet. Just that it would be appreciated.

    No. Not a chance.

    Although I am pleased to see that Brian Rose is starting to drift out, so thanks to whoever it was who recommended laying him.
  • IanB2IanB2 Posts: 51,087
    glw said:

    They are taking a pessimistic interpretation of the admittedly limited data and not approving the use of the vaccine for the very group that could benefit the most. That might be fine if this was any other disease, but right now that will almost certainly result in thousands of avoidable deaths.
    It's known that vaccines are generally less effective for the elderly, and the normal approach is to play around with different doses and dosage regimes to find the best approach for older patients. Understandably this hasn't been done during the highly accelerated development and testing process, and the question is to what extent we are prepared to assume the same approach will work reasonably well for everyone, in advance of getting some reliable data.
  • FF43 said:

    This is interesting. The decision to authorise or not authorise the Astrazeneca vaccine for over 65s depends on precisely two datapoints. One in the vaccination group and one in the control group.

    As calculated, an efficacy rate of 6.3%, although this is clearly nonsense

    https://twitter.com/olivernmoody/status/1354781400071860230

    Quite important to note that human biology does not magically change on a person's 65th birthday.

    Whilst you have to break data up for the purposes of a table, efficacy in adults under 65 is highly relevant to efficacy in the 65+ group. For example, someone could say "there is no evidence to suggest the vaccine will work on 39 year olds called Derek who live in Brighton and work in IT, as none have been tested" but that would be nonsense.
  • MaxPBMaxPB Posts: 39,809
    edited January 2021

    England only data out

    1st dose 2nd dose Cumulative Total Doses to Date
    Total 251,902 1,090 252,992
    East Of England 24,773 51 24,824
    London 41,254 298 41,552
    Midlands 41,416 75 41,491
    North East And Yorkshire 38,606 76 38,682
    North West 38,266 408 38,674
    South East 37,176 125 37,301
    South West 28,317 53 28,370

    What kind of panic do you think we should go for? Running round with hair on fire? War with Erewhon?

    The Pfizer supply pressure clearly biting, AZ supply lower than expected too. Hopefully by the end of next week we'll be back to normal hitting 3m+ per week.
  • glwglw Posts: 10,349
    MaxPB said:

    It seems like a huge public health risk and if in two or three weeks the single jab shows the expected 70% immunity from symptoms in the UK I really hope they reverse this decision.

    It's probable that they will end up reversing the decision, so all this will have accomplished is a further delay.

    It's really not about whether or not a vaccine prevents COVID-19, where the data is muddled, it should be about whether it prevents severe disease and in that regard all vaccines that are approved look to be very good. That is the what has driven the decisions in the UK, granting immunity and reduced transmission are a bonus but not the goal right now.
  • MalmesburyMalmesbury Posts: 54,114

    Now I think it is undisputable there are supply issues here in the UK....but our government aren't going full metal Cartman.
    If anyone asks I am going traditional on this

    https://www.youtube.com/watch/bOR38552MJA
  • Dura_AceDura_Ace Posts: 14,291
    TOPPING said:

    2CV? Does that mean you'll be heading to the country, with a dozen eggs and, erm, a top hat any time soon?
    I've always had 2CVs since my time at university in France. I've currently got an '87 Spécial that's SORNed. I am putting it back on the road because it makes me feel some kind of way.
  • FF43 said:

    This is interesting. The decision to authorise or not authorise the Astrazeneca vaccine for over 65s depends on precisely two datapoints. One in the vaccination group and one in the control group.

    As calculated, an efficacy rate of 6.3%, although this is clearly nonsense

    https://twitter.com/olivernmoody/status/1354781400071860230

    Love the way they have a confidence interval of -1405%-94.2% and think it is helpful to show the 94% figure to a decimal place.
  • CarnyxCarnyx Posts: 44,617

    Well that is one way of describing it but it's yet another gift from the Tories to the SNP, free gratis and for nothing.

    The Scots have made up their minds about Boris and there's nothing he can do to change that.
    It's not as if Mrt Johnson ever meets any random members of the Scottish public, either - though neither did Ms May have the guts to do so. I rather feel the incident of Mr Cameron and the porridge factory rather put the Tories off that for good.
  • TOPPINGTOPPING Posts: 43,668

    Now I think it is undisputable there are supply issues here in the UK....but our government aren't going full metal Cartman.
    Aren't these the supply issues that we were warned about weeks ago?
  • Andy_CookeAndy_Cooke Posts: 5,045

    If Vaccine-gate has exposed the EU's systemic weaknesses to a much wider audience, then that has implications.

    Why? well because the people who told us the EU was wonderful and we would shrivel and die without it are pretty much the same people who tell us

    Lockdowns are inevitable and necessary
    America has a liberal majority that was cheated in 2016 and triumphed in 2020
    and
    There's a climate emergency.

    And given these folk have been so spectacularly wrong about the EU, maybe some of their other beliefs are worth examining in more detail going forward

    Wow, that's an amazing connection to make.

    "If the EU are unpleasant to us, then that means lockdowns are unnecessary!"

    I'm genuinely speechless.
  • FrancisUrquhartFrancisUrquhart Posts: 83,371
    edited January 2021
    The drawn out and leaking process of the European approval is really bad. It has allowed fake news and now excitable journalists jumping on all sorts of conflicting titbits of info.

    I have to say very impressed here how both the announcement of trial results and approvals were calmly and quietly handled here. The only one where there was any leak of its next week, its next week, was AZN, and nothing more than that.

    For all the other announcements, it literally appeared out of nowhere at 6am on a Monday morning.
  • kle4kle4 Posts: 98,426

    England only data out

    1st dose 2nd dose Cumulative Total Doses to Date
    Total 251,902 1,090 252,992
    East Of England 24,773 51 24,824
    London 41,254 298 41,552
    Midlands 41,416 75 41,491
    North East And Yorkshire 38,606 76 38,682
    North West 38,266 408 38,674
    South East 37,176 125 37,301
    South West 28,317 53 28,370

    What kind of panic do you think we should go for? Running round with hair on fire? War with Erewhon?

    Good thing they primed about some reduction in supply this week. Vital Feb target under threat.
  • RobDRobD Posts: 60,336
    Full approval. What was that 8% bollocks about then?
  • If Vaccine-gate has exposed the EU's systemic weaknesses to a much wider audience, then that has implications.

    Why? well because the people who told us the EU was wonderful and we would shrivel and die without it are pretty much the same people who tell us

    Lockdowns are inevitable and necessary
    America has a liberal majority that was cheated in 2016 and triumphed in 2020
    and
    There's a climate emergency.

    And given these folk have been so spectacularly wrong about the EU, maybe some of their other beliefs are worth examining in more detail going forward

    52% of people voted Leave.

    Zero constituencies in the UK would have voted Trump
    About 90% of UK think the lockdown is either right or doesn't go far enough.
    13% of the UK denies climate change.

    Your idea to link those ideas together is mad.
  • Or if you're a paranoid fool who projects emotions onto others.

    I see more anger than glee. With an element of "I told you so" at the worst.

    Next time you criticise anyone should I use the word "glee" about your emotions at the time?
    glee
    /ɡliː/
    noun
    noun: glee; plural noun: glees
    1. great delight, especially from one's own good fortune or another's misfortune.
    "his face lit up with impish glee"

    Nope, you're right, none of that whatsoever.
  • kle4 said:

    Most people will probably hear something like that as meaning unsafe, even when under that worst case it's still technically better than nothing. But if its insufficient data behind decision leaking that it is proven low efficacy is reckless.
    Quite. They are making no effort to manage the message, and everyone suffers.
  • RobDRobD Posts: 60,336

    The drawn out and leaking process of the European approval is really bad. It has allowed fake news and now excitable journalists jumping on all sorts of conflicting titbits of info.

    I have to say very impressed here how both the announcement of trial results and approvals were calmly and quietly handled here. The only one where there was any leak of its next week, its next week, was AZN, and nothing more than that.

    For all the other announcements, it literally appeared out of nowhere at 6am on a Monday morning.

    Especially the head boffin leading the press conference. Clearly on top of her brief.
  • BromBrom Posts: 3,760

    England only data out

    1st dose 2nd dose Cumulative Total Doses to Date
    Total 251,902 1,090 252,992
    East Of England 24,773 51 24,824
    London 41,254 298 41,552
    Midlands 41,416 75 41,491
    North East And Yorkshire 38,606 76 38,682
    North West 38,266 408 38,674
    South East 37,176 125 37,301
    South West 28,317 53 28,370

    What kind of panic do you think we should go for? Running round with hair on fire? War with Erewhon?

    We're still managing over 2m a week which is great but we will fall short of the Feb 15th target unless we can get back up to last week's levels by next week.
  • CarnyxCarnyx Posts: 44,617
    Dura_Ace said:

    I've always had 2CVs since my time at university in France. I've currently got an '87 Spécial that's SORNed. I am putting it back on the road because it makes me feel some kind of way.
    My chum and I used to go megalith-hunting in his in the 1980s. The peel-back top was great for doing a Rommel impersonation to look over the hedges for the osbcure sites we were ticking off.
  • RobDRobD Posts: 60,336

    Love the way they have a confidence interval of -1405%-94.2% and think it is helpful to show the 94% figure to a decimal place.
    Are they even numerate? The prior distribution on effectivity should be bounded between 0-100.
  • DumbosaurusDumbosaurus Posts: 856
    edited January 2021
    Endillion said:

    No. Not a chance.

    Although I am pleased to see that Brian Rose is starting to drift out, so thanks to whoever it was who recommended laying him.
    Been on the Rose train a few times - I'd be curious to know if it's directly him interfering in Betfair, or if it's Paddy (or similar) laying off risk (clearly he's interfering with the market somewhere, just unsure if it's Betfair0. It's violent when it happens but it has been consistent so far and I certainly wouldn't be laying him at these prices* with such little depth below - back him and wait for him to come back. If he doesn't again, well no great matter...

    *At time of writing last print is 25 but not much there until 11
  • kinabalukinabalu Posts: 44,716
    glw said:

    They are taking a pessimistic interpretation of the admittedly limited data and not approving the use of the vaccine for the very group that could benefit the most. That might be fine if this was any other disease, but right now that will almost certainly result in thousands of avoidable deaths.
    The NHS emergency - grave and projected to be catastrophic without urgent action - surely had much to do with us approving the AZ vaccine at a lower than ideal confidence level on efficacy. Same thing applies to our decision to defer the booster and do more 1st jabs.

    Perhaps Germany is not in quite such a crisis situation?
  • The capacity for 500k/day is there. I wouldn't be surprised if the government just miss their target. I said from the start they should have gone for the RyanAir approach, say mid March and then when you do it by end of Feb, can claim success.

    However, I hope the media can resist their urge to screech about this. It clearly isn't the UK fault and are still doing very well.
  • RobD said:

    Are they even numerate? The prior distribution on effectivity should be bounded between 0-100.
    Apparently effectiveness can be negative if it makes you more likely to catch the disease (ie it harms rather than helps your immune system).
  • tlg86tlg86 Posts: 26,517
    Brom said:

    We're still managing over 2m a week which is great but we will fall short of the Feb 15th target unless we can get back up to last week's levels by next week.
    The EU histrionics are good news for the government. They've demonstrated that there is the ability to hit the target, but clearly supply is the limiting factor. But we say that Pfizer and AZN are doing their best etc. etc.
  • TheuniondivvieTheuniondivvie Posts: 43,242
    edited January 2021
    Carnyx said:

    It's not as if Mrt Johnson ever meets any random members of the Scottish public, either - though neither did Ms May have the guts to do so. I rather feel the incident of Mr Cameron and the porridge factory rather put the Tories off that for good.
    Ms May did pursue the high risk strategy of chapping a few doors in Deeside at least, so she has more balls than BJ.
  • RH1992RH1992 Posts: 788

    Now I think it is undisputable there are supply issues here in the UK....but our government aren't going full metal Cartman.
    "Tight but we're confident of meeting our target" suggests that the government have the capacity to deliver but not the supply at present but think that more is on the way. Hopefully there's a big batch incoming, as it's easily possible for us to be doing 500k a day if the supply is there as demonstrated last week.
  • RobDRobD Posts: 60,336

    Apparently effectiveness can be negative if it makes you more likely to catch the disease (ie it harms rather than helps your immune system).
    Let's hope it doesn't make oldies 10x more likely to get it. That would be a sub-optimal outcome.
  • felixfelix Posts: 15,180

    Surely the best way to troll the EU is to offer all of the European Commissioners priority AZ vaccines administered here in the UK as part of our effort to recognise their importance in strong bilateral relations?

    I understand that anal injections with thick needles may be more efficacious for the stubborn patients.........
This discussion has been closed.